الملخص

The aim of this study was to determine the histopathological study of oxidative stress by H2O2 on hepatic and renal tissues of female mice. Liver histological section for a control positive group animal showed moderate to severe central vein congestion loss of regular arrangements of hepatic cords with hepatocytes vacuolation .Whereas, renal histological section revealed atrophy of glomeruli with severe interstitial congestion and tubular epithelia necrosis. Furthermore, liver histological section for a Fadrozole treated group animal revealing the mild to moderate portal vascular congestion, with mild hepatocytes vacuolation and mild inflammatory cells infiltration in portal area; whereas, kidney histological section for this group animal revealed the characteristic close to normal glomeruli, with intact renal tubules epithelia, but characteristic close to normal glomeruli , with intact renal tubules epithelia with significant brush borders. Whereas, liver histological section for a PLGA loaded Fadrozole treated group animal revealed the slight vascular congestion ,with mild hepatocytes swelling; but kidney histological section for this group animal showed the normal glomeruli , with degenerative renal. Obtained data and review of literature suggested that H₂O₂ and estrogen preparations could be responsible for toxic damage of mice liver and kidney, described as fatty change, vascular disorders, hepatic, and focal nodular hyperplasia., tubules epithelia. the normal glomeruli with degenerative renal tubules epithelia. This study concluded that PLGA loaded Fadrozole had the ability in ameliorating harmful oxidative stress