الملخص

The current study evaluated the harmful effects of trichloroethylene and curcumin on the reproductive system in male Wistar rats.  For 12 weeks, animals were given 0.2ml/100 g B.W of each (trichloroethylene, curcumin, and corn oil as controls) via gavage. The study found significant differences in testosterone levels among the three groups, with the curcumin group having the highest mean concentration (0.978 ng/ml), indicating a stimulatory or protective effect on testosterone production. Trichloroethylene (TCE) treatment resulted in significantly decreased testosterone levels (0.580 ng/ml), indicating probable endocrine disruption and impaired hormone synthesis. Sperm analysis found that the curcumin group performed better than the TCE and control groups, with higher sperm count, motility, and viability, as well as fewer sperm abnormalities, supporting curcumin's protective effect in sperm quality maintenance. Histopathological tests confirmed these results: TCE exposure produced significant testicular necrosis, congestion, and the degeneration of seminiferous tubules. The curcumin group revealed degenerative alterations but still had some spermatogenic function. The oil control group showed symptoms of testicular degeneration, including macro-vacuolar alterations and a reduction in Leydig cells. Overall, curcumin appears to reduce TCE's reproductive toxicity by increasing hormone levels, sperm parameters, and testicular tissue integrity.