الملخص

The study aim to investigate the mitigating effect of Saffron on body weight and oxidative stress in male rats exposed to streptozotocine to induced Diabetes Mellitus. 40 male rats aged 8-10 weeks included in this study, it divided to 4 group.10 male rats don’t receive any type of treatment and only injected an equal volume of vehicle. Saffron group:  10 male rats receive daily orally dose of Saffron extract 500mg/kg/bw daily for 28 days. Streptozotocin group :10 male rats  received only one single I/P injection of streptozotocin  65mg/kg /bw. Streptozotocin + Saffron group: 10 male rats receive one single I/P injection of streptozotocin  65mg/kg/ BW, followed by daily orally dose of Saffron extract 500mg/kg /bw for 28 days.   The results showed a significant improvement (p≤ 0.05) in body weight and oxidative stress values in the saffron + streptozotocine group compare with streptozotocine alone group. In conclusion, Saffron has an enhanced effect on the body weight and oxidative stress  in diabetes mellitus induced rats.