الملخص

Vinylcyclohexene Diepoxide (VCD)  kills  small pre-antral follicles, especially primordial and primary follicles, The bioactivation of VCD in the ovary results in accelerated atresia of these early-stage follicles.   This focused follicular destruction disrupts the ovarian reserve, which leads to ovarian failure. The aim of the study includes effect of VCD on the level of estrogen, And evaluating of  alterations in ECG parameters associated with estrogen depletion . rats randomly divided into two groups,the first set as control group ,in the second group the rats where received vinylcyclohexene (VCD) 80 mg/kg BW/daily for 2 weeks as a VCD group. In the current study there was a significant (p≤0.05) decrease in the level of estrogen in the serum (17.40±0.17) in the VCD group compared to the control group (10.22±0.41) . the results of this study showed a significant decreased (p ≤ 0.05) in waves of aterial depolarization (P) (1.49 ± 0.09), ventricular depolarization (QRS)(6.22  ± 0.38),ventricular repolarization (T)( 1.474  ± 0.18 ) time in the VCD group as compare with control group (p)( 4.65 ± 0.35 ) ,QRS (16.56  ± 1.2),T (2.544b  ± 0.1)  increase in voltage of waves  0.052  ± 0.002 MV (P) 0.04  ± 0.004 (QRS) in the VCD group compare to control group 0.02  ± 0.001 (p), 0.024  ± 0.002 (QRS) while there was no significant difference in T wave between control (0.06  ±0.001) and VCD group (0.07  ± 0.004 ) . there is a decrease in the level of estrogen in the  VCD group that was injected with the VCD, and this depletion causes an increase in the heart voltage.