الملخص

This work aimed to identify the biological agent, in the aqueous extract of soursop leaves (Annona muricata), to identifying oxidative stress induced by Allura red E129, using the latter as a model. For 30 days, rats were divided into four groups. Group 2 received two weekly orally administered of Allura red at a dose of 0.4 mg/kg body weight, unlike Group 1, which served as the control group. Group 3 received an aqueous extract of soursop leaves at a concentration of 400 mg/kg.Group 4 received an aqueous extract of soursop leaves at a concentration of 400 mg/kg daily, four hours before receiving Allura red E129. Results: The results of this study indicate that A. muricata is also effective in protecting against the pathogens associated with Allura red E129, as evidenced by the associated degenerative cell expression, congestion, glomerular shrinkage, and Bowman's absence. By decrease ALT, AST and ALP, a 400 mg/kg aqueous extract of A. muricata was observed to significantly reduce the effects of Allura red in rats. Furthermore, the extract demonstrated enhanced oxidative stress defense against toxicity from A. muricata L. golders, exhibiting antioxidant activity.