الملخص

Moringa oleifera is a medicinal plant widely recognized for its rich content of bioactive compounds such as flavonoids, phenolic compounds, alkaloids, tannins, saponins, vitamins, and antioxidants that contribute to its therapeutic potential against various pathological disorders, including gastric ulceration. The present study aimed to evaluate the therapeutic effects of Moringa oleifera extract and lansoprazole against indomethacin-induced gastric ulcers in rats. Ulcer-induced rats exhibited several clinical manifestations, including lethargy, anorexia, and melena, accompanied by a significant decrease (P < 0.05) in body weight to accomplish this, Forty adult Wistar rats were divided to 5 groups(n=8): control (C−) Administration of Distilled water (D.W) for 4weeks (orally) and other 4 groups induced gastric ulcer by administration with a single oral dose of indomethacin (30 mg/kg BW).  Control positive (C+): (8 rat) Induced with acute gastric ulcer without any treatments. G1:(Moringa treatment): after 3 days of ulcer induction, administration with 200 mg/kg of Moringa leaf extract orally, for 4 weeks. G 2: (lansoprazole treatment): after 3 days of ulcer induction, administration with 20 mg/kg of lansoprazole orally for 4 weeks. G3: after 3 days of ulcer induction, administration with combination of MO (200mg/kg) and lansoprazole (20mg/kg) orally for 4 weeks. following ulcer induction. Treatment with Moringa oleifera extract significantly improved (P < 0.05) body weight and clinical condition compared with the untreated ulcer group, while rats treated with lansoprazole demonstrated a greater degree of recovery. Notably, the combination therapy produced the most pronounced therapeutic effect, showing significant amelioration (P < 0.05) of clinical signs and restoration of body weight compared with all other treated groups. Prostaglandin levels were significantly elevated (P < 0.05) in all treated groups relative to the untreated ulcer group. The highest prostaglandin concentration was observed in the combination-treated group, followed by the lansoprazole-treated group, whereas the Moringa oleifera-treated group showed the lowest increase among the treated groups. Histopathological examination further confirmed the therapeutic efficacy, revealing marked improvement in gastric mucosal architecture and a significant reduction in tissue damage in treated animals, particularly in the combination therapy group. These findings suggest that Moringa oleifera possesses significant anti-ulcer activity and may enhance the therapeutic efficacy of lansoprazole through prostaglandin modulation and improvement of gastric histopathological alterations.