الملخص

     Estrogen is integral to brain health, influencing neuroprotection, cognition, mood, and development. The neurological effects of exposure, in particular its possible neurotoxic effects on the brain, have drawn more and more attention in research The aim of this study is to detrain the effect of decrease of estrogen on the brain. A total of ten healthy female rats are used in present work which was divided into two groups. The first group contains 5 rats will served as control group injected IM normal saline. The second group contains 5 rats injected IM (VCD) ( 80mg/kg) for 2 weekly . After the experiment was completed, blood was drawn from the animals and serum was extracted to test GSH, estrogen, and MDA. Brain samples were also taken to measure the gene expression of alpha and beta estrogen in the brain. The current study showed that there was a decrease in the amount of serum estrogen and GSH in the group exposed to the VCD when compared with the control group, and that there was an increase in the amount of Malondialdehyde in the group exposed to the VCD when compared with the control group.The results of gene expression showed that there was a decrease in the expression of the gene estrogen alpha in the group exposed to the VCD when compared with the control group, and that there was an increase in the gene expression of the gene estrogen beta in the group exposed to the VCD when compared with the control group.

      Through the current study conclude that the VCD decrease the estrogen inside the body, which led to a decrease in antioxidants and an increase in oxidizing substances, also damage to the ovaries which change in the production of both alpha and beta estrogen receptor in brain