الملخص

Diabetes mellitus (DM) is a chronic disorder of carbohydrate metabolism characterized by abnormal persistent state of hyperglycemia which is associated with lipid metabolic disorders and oxidative stress.This study aimed to compare the effects of green coffee bean extract (GCBE) and berberine for the amelioration of STZ-induced hyperglycaemia in male adult rats. Thirty adult male rats were used and divided randomly into six experimental groups (5 rats/group) as follows: control, cloud of strep /streptozotocin-induced diabetes group, berberine treated group alone, green coffee-treated group alone, streptozotocin + berberine-treated group and streptozotocin + green coffee (Coffea arabica)-treated groups. Experimental diabetes was induced using streptozocin (45 mg/kg body weight). Diabetes was defined as fasting blood glucose ≥ 200 mg/dl after 48 hours. The oral treatment lasted for a period of 8 consecutive weeks.

The biochemical analysis included blood glucose, lipid profile parameters and oxidative stress biomarkers (malondialdehyde (MDA) & glutathione(GSH&& superoxide dismutase(SOD) ). The findings revealed that diabetic rats induced by STZ showed increased hyperglycemia, dyslipidemia and oxidative stress as compared to control. The administration of GCBE and berberine also improved most of the biochemical parameters. Green coffee extract exhibited more pronounced antihyperglycemic and antioxidant activities as compared to the cholesterol-lowering effect of berberine.