الملخص

Wound healing is a complex process involving tissue remodeling, cellular proliferation, and inflammatory responses  of their antioxidant, anti-inflammatory and collagen-supporting qualities, Aloe vera and PRP are widely recognized for their ability to heal wounds. Aims to evaluate the synergistic effect  of efficacy of combined Aloe vera extract and PRP in healing full-thickness skin wounds in a rabbit model  over through microscopic assessment of skin wounds,of skin wounds, including evaluation of wound characteristics and related  histopathological indicator and histological indicator analysis using Hematoxylin and Eosin (H&E). Methods Forty male rabbits were split into two groups: the control group received  (untreated), while the treatment group received (Aloe vera + PRP).  Full -thickness incision were created on the dorsum of each rabbit  had full-thickness incisions made on its dorsum, and treatments were given every day for three, seven, fourteen, and twenty-one days. Results: When compared to the control group, the combination therapy group had the most wound closure and reduction in the wound area. The histopathological examination revealed accelerated re-epithelization  with increased collagen deposition and denser granulation tissue   combined therapy group's histological examination revealed increased collagen deposition, thick granulation tissue, and almost total re-epithelialization. The entire surface of the wound is covered in a continuous layer of epidermis, signifying complete re-epithelialization of the separate layers.  The dermis beneath the epidermis appeared to be securely bonded. The dermal structure becomes more ordered, and connective tissue resembles the dermis of healthy skin. Conclusion: These findings suggest that PRP and AloeVera work in concert to improve tissue repair and speed up the healing of wounds. The combo treatment might be a more effective therapeutic approach for wound care.