الملخص

The current study was designed to investigate some biological effects of the pesticide Permethrin in male white rats. As a result of the present study revealed a significant increase in the concentrations of liver enzymes (AST, ALT, and ALP), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) at a probability level of (P < 0.05) in the treated group (T1) which was administered Permethrin at a concentration of 75mg/kg for 45 day. Additionally, the findings revealed a significant decrease in the concentrations of antioxidants (SOD and CAT) in the treated group Tat the aforementioned probability level.

   On the other hand, the results demonstrated a significant decrease in the concentrations of liver enzymes (AST, ALT, and ALP), MDA, TNF-α and IL-6 in the groups T2, T3, and T4 (treated with Permethrin + Selenium, Permethrin + 6-Shogaol, and Permethrin + Selenium + 6-Shogaol simultaneously, respectively) compared to the treated group T1. A significant increase in the concentrations of SOD and CAT was observed compared to T1 at the specified probability level . As for the histological study of the liver of male rats in the treated group T1, it revealed severe adipose steatosis with infiltration of inflammatory cells, particularly macrophages, and dilation of hepatic sinusoids. Conversely, the results of groups T2, T3, and T4 showed a clear improvement in hepatocytes, which appeared radially arranged around the central vein with mild adipose degeneration