الملخص

The study has been conducted to evaluated the efficacy the blend of organic and essential oil in commercial preparation Keprofix® Oral in dogs. Ten male dogs have been divided in two group; group(A) treated with Keprofix® Oral while group (B) given distal water only. Blood samples were collected from both groups every two weeks until the 12th week these samples have been used to study blood and serum biochemical analysis which have been reveled significant differences in the values of (RBCs count, hemoglobin, PCV, total leukocytes count, neutrophils. lymphocyte, total protein, Albumen, plasma fibrinogen, ALT and serum globulin) at P≤5. Respectively. after 12th week the challenge dose 1×108 CFU of bacteria (E.coli) was given orally to both groups and recorded the clinical signs after that sacrifice the animals and study the histopathological change in liver, spleen and intestine which showed characteristic features represented by increased the length and width of intestinal villi in treated animals with Keprofix® Oral in contrast to non-treated animals also same changes reveled in liver and spleen represented with infiltration of neutrophils in liver parenchyma with lymphocytic hyperplasia in spleen for treated animals with Keprofix® Oral