الملخص

The present study evaluated the hepatoprotective action of Abutilon indicum aqueous extract on heat stress–induced liver damage in male Wistar albino rats. Heat stress causes oxidative stress, inflammation, and hepatocellular damage, ultimately leading to liver functional disturbance and necrosis. Twenty-four male rats were randomly assigned to 3 groups as follows (n = 8 per group): Group A, the control, was treated with normal saline (0.9% NaCl); Group B was exposed to heat stress for 3 h a day at 39-40°C for 30 days ; and Group C received heat exposure followed by oral administration of aqueous extracts of Abutilon indicum (100 mg/kg body weight) for one month. The results of this study revealed a significant decrease in biochemical parameters (Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (BT) in Group C, compared to Group B. Additionally, the histological analysis identified severe hepatocyte necrosis, along with inflammation and hepatocellular degeneration in Group B, while Group C showed a significant positive effect on the biochemical parameters of the rats’ liver damage induced by heat stress. In conclusion, Abutilon indicum has hepatoprotective qualities and could be used as a natural remedy to lessen animal liver damage brought on by heat stress.