الملخص

Despite the beneficial effects of zinc oxide nanoparticles (ZnO-NPs) on different biomedical applications, including their antioxidant and anti-inflammatory ones, it might have cytotoxic and genotoxic impacts on the male reproductive system. Although some researchers were using zinc oxide nanoparticles are beneficial to body organs due to its antioxidant and anti-inflammatory effects, it has also been found to have a harmful effect on the male reproductive system. Objective: The current study aimed to revealed the effect of zinc oxide nanoparticles on male rats’ reproductive performance and histopathology changes for sexual organs for example testes. Materials and Methods: a number of twenty healthy white male rats, aged approximately 7-9 weeks, were randomly divided into two groups and subjected to the following treatments. Group 1 (n=10), were treated with 0.5 ml of aseptic normal saline save as the control negative group. Group 2 (n=10): were Injected with (0.5ml) of ZnO-NPs 350 mg/kg b.w orally for 2 weeks. At day7 and day 21 post injection, rats were anesthetized and sacrificed for histopathological examination. Results: It was shown that ZnO-NPs have a harmful effect on the male reproductive system by distorted seminiferous tubules, severe desquamation and necrosis and absence of spermatocytes and most Sertoli cells Conclusion: It can be concluded that zinc oxide nanoparticles, administered at 350 mg/kg, had the most harmful and toxic effect on male reproductive system.