Effect of Curcumin on Sperm Parameters in Alloxan Induced Diabetes in Mice

Abstract

Diabetes mellitus is a metabolic disorder that negatively affects different body organs. Induced type2 diabetes mellitus (T2DM) lead to hyperglycemia that if chronic might affects spermatogenesis and nuclear content of sperm in male mice. In the current study, diabetes was induced in male albino mice by single i.p. injection of Alloxan (120 mg/kg). For controlling diabetes, metformin (200mg/kg/day) and or curcumin (100mg/kg/ day) were administered orally for 35 days. Male mice (n=40) were divided equally into five groups. Control, Induced Diabetes mellitus (DM), Diabetic treated with curcumin (DM+C), Diabetic treated with metformin (DM+M), Diabetic treated with curcumin and metformin (DM+CM). The results of the current study showed that curcumin and metformin reduce blood glucose level in diabetic mice (p<0.001). Also, metformin alone or in combination with curcumin reduce the rate of abnormalities and DNA damage of sperms at the end of the experiment (p<0.05). In conclusion, curcumin with metformin has beneficial effect in reducing abnormalities and DNA fragmentation of sperm. Further study to investigate the effect of curcumin and metformin on post fertilization outcome in diabetic mice is suggested