Abstract
A laboratory study was conducted to evaluate the histological effects of vaginal infections caused by different types of bacteria and fungi using female rats. The rats were divided into four main groups: a control group (uninfected), two groups infected with Staphylococcus aureus and Enterobacter cloacae, and a fourth group infected with the fungus Candida albicans. Histological sections taken from the vagina and uterus after injecting 0.1 ml of each microbial suspension into the vaginal canal of the rats showed histological changes characterized by congested capillaries and infiltration of neutrophils and lymphocytes in the submucosal areas. This leads to mild focal vaginitis, endometritis, moderate neutrophilic infiltration, and congested blood vessels in the ovarian cortex. Blood analyses from the experimentally infected rats showed some abnormalities resulting from the dynamics of infection and immune responses. Bacterial infections stimulated a neutrophilic and monocytic response accompanied by a compensatory increase in platelet count, while fungal infections led to disruption in hematopoiesis (myelopoiesis) and exacerbated general cytopenia. The type of infection is a decisive factor in determining hematological patterns.