Abstract
This study was conducted to examine the ameliorative Impact of (Silymarin) on Monosodium Glutamate Toxicity. Twenty-eight local male rabbits aged between 3-4 months were divided randomly into four equal groups (7 rabbits of each) housed in experimental cages of the animal house. The animals in first group were fed basal diet as control group (C), second group (T1) was fed basal diet and supplied Monosodium glutamate (10 mg/100g of BW) orally, third group (T2) was supplied with water containing Monosodium glutamate (10 mg/100 g of BW) and Silymarin(0.6 mg/100 g of BW) orally and fourth group (T3) was supplied containing Monosodium glutamate (10 mg/100 g of BW) dissolved in water and Silymarin(1.2 mg/100 g of BW) orally. The results showed that, Hemoglobin concentration was increased with time progress in (T3) group , but the treated MSG groups recorded significant (P< 0.05) lower values than the control group along must studied period. lymphocyte percentage in the T1 and T2 groups showed significant (P< 0.05) higher value than other groups, Monocyte percentage showed that T3 group significantly (P< 0.05) reduction in cholesterol concentration in all time of this study compared with other groups. While T3 group showed significant (P< 0.05) higher than other groups in all time of this study. Triglyceride concentration in T1 group showed significantly (P < 0.05) higher values than control group at 63 days. The concentration of Alanine Aminotransferase (ALT) of rabbits in T1 group (MSG) showed significant (P≤ 0.05) higher value compared with other groups in 63 day period, While showed significantly (P≤0.05) lower value of C , T3 groups compared with the T1, T2 groups in all time of this study. The concentration of Aspartate transaminase enzyme (AST) showed significant increases (P≤0.05) in T1 group (MSG) at all time of the study compared with the other groups .While T3 was recorded significant (P≤0.05) lower value compared with other groups in last stage of the study period. Creatinin concentration in T2 group showed significantly (P < 0.05) higher value than the other groups at the 63 days studied period. In conclusion, it was conducted that there were toxic effects of MSG on male rabbits through increase the damage in the liver and Kidney and oxidative stress through elevation in ALT, AST enzymes, creatinine and cholesterol. Also, with adding Silymarin daily in a dose of (1.2mg/100g BW) showed ameliorative Impact of (Silymarin) on Monosodium Glutamate Toxicity.