Abstract
The study aimed to analyze the impact of the aqueous extract of Agrimony (AE) (Agrimonia eupatoria L.) on the hepatotoxic outcomes induced with the aid of orlistat (ORL) in grownup male albino rats on few physiological parameters. The study was performed on 20 male albino rats, which had been randomly divided into four groups, with 5 animals per group. Their a long time was among three to four months, and their weights ranged among 275-375 g, for 30 days, as follows:
The first institution (G1) changed into given 1 ml of distilled water (DW) each day and served as the control group (negative). The second institution (G2) was given orlistat (ORL) (32 mg/kg) and served as the control group (positive). The third group (G3) was given aqueous extract of agrimony (AE) at a dose of four hundred mg/kg. The fourth institution (G4) turned into given the agrimony extract (AE) (four hundred mg/kg) first, accompanied three hours later by a dose of orlistat (ORL) (32 mg/kg) and served as the preventive organization.
Results: The results confirmed a great increase (P≤0.05) in the stages of liver enzymes AST, ALT, and ALP, and a large decrease (P≤0.05) in the concentrations of general protein, albumin, and globulin within the advantageous control (G2) in comparison to the manage organization (G1). However, the effects additionally indicated a widespread decrease (P≤0.05) in liver enzymes in the G3 and G4 agencies compared to the G2 group, and a significant boom (P≤zero.05) in the 3 proteins in comparison to the G2 institution.
Conclusion: We finish from the above that the use of agrimony (AE) might also have protective potential towards the consequences of acute liver toxicity as a result of the drug Orlistat and can enhance physiological changes, bringing them toward regular.