Abstract
Homocysteine (Hcy), an amino acid that contains thiols and is naturally formed when methionine and cysteine are exchanged . there is a noticeable rise in Hcy in blood plasma is called hyperhomocysteinemia ( HHcy) , which cause cardiovascular disease , cerebrovascular disease and liver tissue destruction . Twenty male rats, participated in the experiment. The rats were split up randomly into HHcy group and control group for 21day of the study , Rats in the HHcy group were given normal diet plus methionine orally ( 1ml/200g BW ) , Rats in control group were given normal diet . At the end of the exposure period, rats was sacrified, and the liver is taken out for histological examination , Haematoxylin and Eosin (Hand E) stain was used to stain the sections . the current study showed a dilated central vein with indistinct hepatocyte swelling and edematous material .